Oxycodone and acetaminophen combination can cause serious unwanted effects or fatal overdose if taken by children, pets, or adults who are not used to strong opioid pain medicines. Oxycodone acetaminophen is a prescription drug used for the management of moderate to severe pain. Learn about side effects, dosages, drug interactions, and more. This combination medication is used to help relieve moderate to severe pain. It contains an opioid pain reliever (oxycodone) and a non-opioid pain reliever (acetaminophen). Oxycodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever. Oxycodone/acetaminophen is a combination pain -relief (analgesic) medication prescribed to treat acute moderate-to-severe pain. Oxycodone is an opioid analgesic, while acetaminophen is a nonopioid drug that reduces pain and fever. Find patient medical information for Oxycodone/Acetaminophen (Percocet, Tylox, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user. Oxycodone and acetaminophen tablets are used to manage pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate, and when other pain treatments such as non-opioid pain medicines do not treat your pain well enough, or you cannot tolerate them. Take this medicine by mouth with a full glass of water. Take it as directed on the label. You can take it with or without food. If it upsets your stomach, take it with food. Do not take it more often than directed. There may be unused or extra doses in the bottle after you finish your treatment. Detailed Acetaminophen / Oxycodone dosage information for adults. Includes dosages for Pain; plus renal, liver and dialysis adjustments. Each oxycodone and acetaminophen tablet USP 10 mg/325 mg contains oxycodone hydrochloride 10 mg (equivalent to 8.9637 mg oxycodone) and acetaminophen 325 mg. It is available as a white to off-white caplet shaped tablet debossed with “M523” on one side and “10/325” on the other side. Includes Oxycodone and Acetaminophen indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more.